Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.

Olivier Bernard, Nathalie Lecointe, P Jonveaux, +5

PubMed

Expression of TAL-1 proteins in human tissues

Karen Pulford, Nathalie Lecointe, Karen Leroy, +3

Blood

Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface

Sandrine Lécart, Nathalie Lecointe, Arun Subramaniam, +8

European Journal of Immunology

Th2 ClonesT-regulatory CellImmunologyImmunologic MechanismCellular Physiology +15

GATA-and SP1-binding sites are required for the full activity of the tissue-specific promoter of the tal-1 gene.

Nathalie Lecointe, Olivier Bernard, Karine Naert, +4

PubMed

A third tal-1 promoter is specifically used in human T cell leukemias.

Olivier Bernard, Orly Azogui, Nathalie Lecointe, +4

The Journal of Experimental Medicine

Exon 4ChromatinTranscriptional RegulationHematological MalignancyCytogenetics +13

Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion.

Karen Leroy, Marie‐Antoinette Vinit, Nathalie Lecointe, +4

The EMBO Journal

Medium DepletionApoptosisImmunologyCell DeathCellular Immune Response +6

Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the α2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma

Nathalie Lecointe, Joanne Meerabux, M. Ebihara, +2

Oncogene

Lymphoid NeoplasiaTranscriptional RegulationHuman LymphomaPathologyα2 Subunit +6

Distinct DNase-I hypersensitive sites are associated with TAL-1 transcription in erythroid and T-cell lines

Karen Leroy, Vinit Ma, Nathalie Lecointe, +1

Blood

Erythroid-specific Inhibition of the tal-1 Intragenic Promoter Is Due to Binding of a Repressor to a Novel Silencer

C. Courtes, Nathalie Lecointe, Laurent Le Cam, +3

Journal of Biological Chemistry