Noah J. Pyles

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

Jacob R. Mann, Amanda M. Gleixner, Jocelyn C. Mauna et al. · Neuron · 2019 · 547 citations · Full text

Signal Transduction, Molecular Neuroscience, Rna Binding Proteins +6

The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy

Constantin d’Ydewalle, Daniel M. Ramos, Noah J. Pyles et al. · Neuron · 2016 · 133 citations · Full text

Musculoskeletal Research, Degenerative Disease, Novel Therapeutic Target +5

Astrocytes influence the severity of spinal muscular atrophy

Hansjörg Rindt, Zhihua Feng, Chiara Mazzasette et al. · Human Molecular Genetics · 2015 · 128 citations · Full text

Spinal Disorder, Synaptic Signaling, Social Sciences +17

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo

Charlton G. Otte, Tyler R. Fortuna, Jacob R. Mann et al. · Neurobiology of Disease · 2020 · 24 citations · Full text