Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression

Chaonan Liu, Weinian Liao, Jun Chen, +9

Redox Biology

Blood CellMtor Inhibitor RapamycinStem Cell BiologyOxidative StressMyeloid Neoplasia +16

Imbalanced lipid homeostasis caused by membrane αKlotho deficiency contributes to the acute kidney injury to chronic kidney disease transition

Yue Wang, Ran Li, Qigang Lan, +12

Kidney International

Glomerular DiseaseRenal InflammationOxidative StressInflammationMetabolic Syndrome +28

Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance

Changhong Du, Xinmiao Wang, Yiding Wu, +14

Cell Reports

Cellular PhysiologyBone Marrow FailureReceptor Tyrosine KinaseStem Cell MobilizationHematology +18

Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

Weinian Liao, Chaonan Liu, Ke Yang, +16

Cellular and Molecular Immunology

Regenerative MedicineProsurvival MicroenvironmentCell TherapyMedicineStem Cell Mobilization +8

Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury

Changhong Du, Chaonan Liu, Kuan Yu, +14

Cell stem cell

Mitochondrial FunctionMitochondrial DynamicMedicineStem Cell MobilizationPhysiology +7

Caffeic acid attenuates irradiation-induced hematopoietic stem cell apoptosis through inhibiting mitochondrial damage

Xinmiao Wang, Weinian Liao, Jun Chen, +8

Experimental Cell Research

Mitochondrial DamageHealth SciencesMedicineLipid PeroxidationApoptosis +8

Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury

Changhong Du, Yi-Ding Wu, Ke Yang, +15

Military Medical Research

Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl‐xL ubiquitination and degradation

Qigang Lan, Changhong Du, Jiachuan Xiong, +10

Journal of Thrombosis and Haemostasis

GlomerulonephritisUrologyRenal DiseaseRenal FunctionKidney Failure +10

Phosphate Metabolic Inhibition Contributes to Irradiation-Induced Myelosuppression through Dampening Hematopoietic Stem Cell Survival

Yiding Wu, Weinian Liao, Jun Chen, +11

Nutrients

Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury

Weinian Liao, Xinliang Chen, Shuzhen Zhang, +12

Cell Communication and Signaling