Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Michael D. Crowther, Garry Dolton, Mateusz Legut, +16

Nature Immunology

Systems BiologyCancer ImmunosurveillanceImmunologyTumor ImmunityImmune Surveillance +9

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

Anna Bulek, David K. Cole, Ania Skowera, +18

Nature Immunology

Type 1Autoimmune DiseaseHuman Beta CellsDiabetesImmunology +9

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

David K. Cole, Anna Bulek, Garry Dolton, +14

Journal of Clinical Investigation

Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy

Garry Dolton, Cristina Rius, Aaron Wall, +30

Cell

Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

Garry Dolton, Cristina Rius, Md Samiul Hasan, +15

Cell

Optimized Peptide–MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

Garry Dolton, Efthalia Zervoudi, Cristina Rius, +11

Frontiers in Immunology

Structural basis for ineffective T‐cell responses to MHC anchor residue‐improved “heteroclitic” peptides

Florian Madura, P.J. Rizkallah, Christopher Holland, +6

European Journal of Immunology

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

David K. Cole, Kim Miles, Florian Madura, +13

Journal of Biological Chemistry

ImmunologyImmunologic MechanismAntigen ProcessingAutoimmunityT Cell Immunity +5

Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment

Rebecca C. Trueman, Claris Diaz, Tracy D. Farr, +6

Journal of Cerebral Blood Flow & Metabolism

NeuropsychologyBrain FunctionCerebrovascular DiseaseBehavioural TestsWhite Matter Atrophy +25

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

Julia Makinde, Mathew Clement, David K. Cole, +17

Journal of Biological Chemistry