Mengen Chen

Random walk in orthogonal space to achieve efficient free-energy simulation of complex systems

Lianqing Zheng, Mengen Chen, Wei Yang · Proceedings of the National Academy of Sciences · 2008 · 310 citations · Full text

Engineering, Molecular Biology, Conformational Transition +22

Simultaneous escaping of explicit and hidden free energy barriers: Application of the orthogonal space random walk strategy in generalized ensemble based conformational sampling

Lianqing Zheng, Mengen Chen, Wei Yang · The Journal of Chemical Physics · 2009 · 83 citations

Equilibrium Conformational Sampling, Engineering, Physics +15

Profiling the composition and metabolic activities of microbial community in fermented grain for the Chinese strong-flavor Baijiu production by using the metatranscriptome, high-throughput 16S rRNA and ITS gene sequencings

Xiaolong Hu, Kangli Wang, Mengen Chen et al. · Food Research International · 2020 · 65 citations

Biology, Microbial Community, Fermented Grain +12

Practically Efficient QM/MM Alchemical Free Energy Simulations: The Orthogonal Space Random Walk Strategy

Donghong Min, Lianqing Zheng, William T. Harris et al. · Journal of Chemical Theory and Computation · 2010 · 36 citations

Free Energy Changes, Engineering, Computational Chemistry +17

On‐the‐path random walk sampling for efficient optimization of minimum free‐energy path

Mengen Chen, Wei Yang · Journal of Computational Chemistry · 2009 · 29 citations

Path Planning, Engineering, Sampling Method +14