Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

Vishal S. Vaidya, Josef Ozer, Frank Dieterle, +16

Nature Biotechnology

Kidney InjuryTranslational MedicineUrologyRenal FunctionMedicine +9

Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium

Frank Dieterle, Frank D. Sistare, Federico Goodsaid, +62

Nature Biotechnology

Translational MedicineUrologyRenal FunctionMedicineKidney Failure +7

A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function

Josef Ozer, Frank Dieterle, Sean P. Troth, +29

Nature Biotechnology

Translational MedicineUrologyRenal FunctionSerum MarkerMedicine +9

A rapid urine test for early detection of kidney injury

Vishal S. Vaidya, Glen Ford, Sushrut S. Waikar, +11

Kidney International

UrologyRenal FunctionKidney FailureRenal PathologyDiagnosis +4

Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury

Yan Yu, Hong Jin, Daniel Holder, +15

Nature Biotechnology

GlomerulonephritisTranslational MedicineUrologyRenal DiseaseFactor 3 +12

Towards consensus practices to qualify safety biomarkers for use in early drug development

Frank D. Sistare, Frank Dieterle, Sean P. Troth, +34

Nature Biotechnology

Drug SafetyPredictive ToxicologyPreclinical Drug EvaluationSafety BiomarkersPharmacology +8

Integrated Pathway Analysis of Rat Urine Metabolic Profiles and Kidney Transcriptomic Profiles To Elucidate the Systems Toxicology of Model Nephrotoxicants

Ethan Xu, Ally Perlina, Heather Vu, +4

Chemical Research in Toxicology

rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment

Thomas P. Monath, Patricia Fast, Kayvon Modjarrad, +12

Vaccine X

Evaluation of the Relative Performance of 12 Urinary Biomarkers for Renal Safety Across 22 Rat Sensitivity and Specificity Studies

Kateřina Vlasáková, Zoltán Erdős, Sean P. Troth, +9

Toxicological Sciences

Renal PathologyRenal InflammationPathologyGlomerulonephritisRenal Function +22

Clinical development of a recombinant Ebola vaccine in the midst of an unprecedented epidemic

Beth-Ann Coller, Jeffrey T. Blue, Rituparna Das, +15

Vaccine

VaccinationVaccine DevelopmentUnprecedented EpidemicVaccine TargetImmunology +7