Anthony N. Scozzari

Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides:  Adduct Characterization and Avoidance

Daniel C. Capaldi, Hans Gaus, Achim H. Krotz et al. · Organic Process Research & Development · 2003 · 79 citations

Bioorganic Chemistry, Dna, Oligonucleotide Manufacture +20

UnyLinker: An Efficient and Scaleable Synthesis of Oligonucleotides Utilizing a Universal Linker Molecule: A Novel Approach To Enhance the Purity of Drugs

Vasulinga T. Ravikumar, R. Kumar, Phil Olsen et al. · Organic Process Research & Development · 2008 · 54 citations

Synthesis of Antisense Oligonucleotides:  Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent:  From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Zacharia S. Cheruvallath, Recaldo L. Carty, Max N. Moore et al. · Organic Process Research & Development · 1999 · 53 citations

Pharmaceutical Science, Bioorganic Chemistry, Engineering +19

Phosphorothioate Oligonucleotides with Low Phosphate Diester Content:  Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS)

Achim H. Krotz, Dennis Gorman, Paul Mataruse et al. · Organic Process Research & Development · 2004 · 31 citations

Bioorganic Chemistry, Engineering, Molecular Biology +16

Applications of green chemistry in the manufacture of oligonucleotide drugs

Yogesh S. Sanghvi, Vilwanathan Ravikumar, Anthony N. Scozzari et al. · Pure and Applied Chemistry · 2001 · 31 citations · Full text

Engineering, Oligonucleotide Manufacture, Green Chemistry +17