Karen M. Ashe

Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease

Karen M. Ashe, Eva Budman, Dinesh S. Bangari et al. · Molecular Medicine · 2015 · 99 citations · Full text

Glycobiology, Immunology, Biological Therapy +21

Substrate Reduction Augments the Efficacy of Enzyme Therapy in a Mouse Model of Fabry Disease

John Marshall, Karen M. Ashe, Dinesh S. Bangari et al. · PLoS ONE · 2010 · 72 citations · Full text

Enzyme Therapy, Glycobiology, Substrate Reduction Therapy +19

Iminosugar-Based Inhibitors of Glucosylceramide Synthase Increase Brain Glycosphingolipids and Survival in a Mouse Model of Sandhoff Disease

Karen M. Ashe, Dinesh S. Bangari, Lingyun Li et al. · PLoS ONE · 2011 · 72 citations · Full text

Sandhoff Disease, Glycobiology, Immunology +17

Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann–Pick C mice

Jennifer B. Nietupski, Joshua Pacheco, Wei‐Lien Chuang et al. · Molecular Genetics and Metabolism · 2012 · 61 citations

Molecular Pharmacology, Biochemistry, Medicine +11

Systemic Administration of AAV8-α-galactosidase A Induces Humoral Tolerance in Nonhuman Primates Despite Low Hepatic Expression

Jennifer B. Nietupski, Gregory D Hurlbut, Robin J. Ziegler et al. · Molecular Therapy · 2011 · 54 citations · Full text