Malcolm N. Palfreyman

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer

John E. Souness, Miriam Griffin, Christopher Maslen et al. · British Journal of Pharmacology · 1996 · 115 citations · Full text

Immunology, Tnf Alpha, Inflammation +17

Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs

Michael J. Ashton, David Cook, Garry Fenton et al. · Journal of Medicinal Chemistry · 1994 · 112 citations · Full text

Antiparasitic Agent, Pde Iv, Biological Activities +17

Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram

John E. Soilness, Christopher Maslen, Stephen E. Webber et al. · British Journal of Pharmacology · 1995 · 85 citations · Full text

Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium channel opener

Thomas J. Brown, Robert F. Chapman, David Cook et al. · Journal of Medicinal Chemistry · 1992 · 38 citations

Bioorganic Chemistry, Engineering, Organic Chemistry +18

Phosphodiesterase type IV inhibitors as antiinflammatory agents

Malcolm N. Palfreyman · Drugs of the Future · 1995 · 36 citations

Anti-inflammatory, Antiparasitic Agent, Medicine +5