Maria T. Stranieri

Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle et al. · Journal of Medicinal Chemistry · 2003 · 121 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

Thomas J. Tucker, Stephen F. Brady, William C. Lumma et al. · Journal of Medicinal Chemistry · 1998 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Species Variability in Platelet and other Cellular Responsiveness to Thrombin Receptor-derived Peptides

Thomas Connolly, Cindra Condra, Dong-Mei Feng et al. · Thrombosis and Haemostasis · 1994 · 99 citations

Medicine, Biochemistry, Molecular Biology +17

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Philip E.J. Sanderson, Terry A. Lyle, Kellie J. Cutrona et al. · Journal of Medicinal Chemistry · 1998 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor <i>N</i>-(9-Hydroxy-9-fluorenecarboxy)prolyl <i>trans</i>-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

Stephen F. Brady, Kenneth J. Stauffer, William C. Lumma et al. · Journal of Medicinal Chemistry · 1998 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17