Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Christine M. Dejea, Payam Fathi, John M. Craig, +15

Science

Microbiota organization is a distinct feature of proximal colorectal cancers

Christine M. Dejea, Elizabeth C. Wick, Elizabeth M. Hechenbleikner, +26

Proceedings of the National Academy of Sciences

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

Liam Chung, Erik Thiele Orberg, Abby L. Geis, +22

Cell Host & Microbe

InflammationMicrobial ToxinColonic Epithelial CellsPathogenesisPathology +7

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

Angelo C. Lepore, Britta Rauck, Christine M. Dejea, +4

Nature Neuroscience

Astrocyte ReplacementNeurodegenerative DiseasesNeuroregenerationNeurobiology Of DiseaseMotor Neuron Disease +9

Metabolism Links Bacterial Biofilms and Colon Carcinogenesis

Caroline H. Johnson, Christine M. Dejea, David Edler, +15

Cell Metabolism

BiofilmsDysbiosisColon CarcinogenesisMicrobiology

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia

Julia L. Drewes, James R. White, Christine M. Dejea, +14

npj Biofilms and Microbiomes

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic

Sarah Tomkovich, Christine M. Dejea, Kathryn Winglee, +23

Journal of Clinical Investigation

BiofilmsDysbiosisHealthy SubjectsMucosal ImmunologyPathology +11

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

Erik Thiele Orberg, Hongni Fan, Ada Tam, +12

Mucosal Immunology

Myeloid Immune SignatureDysbiosisMucosal ImmunologyPathogenesisImmunology +6

Human Colon Cancer–Derived <i>Clostridioides difficile</i> Strains Drive Colonic Tumorigenesis in Mice

Julia L. Drewes, Jie Chen, Nicholas O. Markham, +28

Cancer Discovery

Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration

Angelo C. Lepore, Christine M. Dejea, Jessica Carmen, +4

Experimental Neurology

Neurodegenerative DiseasesNeuroregenerationHealth SciencesChronic ModelsBrain Injury +12