T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Stefanie Lesch, Viktoria Blumenberg, Stefan Stoiber, +55

Nature Biomedical Engineering

Cancer ImmunosurveillancePancreatic CancerT CellsMedicinePancreatic Tumours +8

Cancer cells induce interleukin-22 production from memory CD4⁺T cells via interleukin-1 to promote tumor growth

Cornelia Voigt, Peter May, Adrian Gottschlich, +17

Proceedings of the National Academy of Sciences

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Adrian Gottschlich, Moritz Thomas, Ruth Grünmeier, +43

Nature Biotechnology

Hematological MalignancyCar-t CellsMixed-phenotype Acute LeukemiaAcute Myeloid LeukemiaMalignant Blood Disorder +9

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

Bruno L. Cadilha, Mohamed-Reda Benmebarek, Klara Dorman, +26

Science Advances

Programmable multispecific DNA-origami-based T-cell engagers

Klaus F. Wagenbauer, Nhi Pham, Adrian Gottschlich, +11

Nature Nanotechnology

EngineeringImmunologyImmunotherapeuticsBiological ComputingImmunotherapy +20

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Daria Briukhovetska, Javier Suárez-Gosálvez, Cornelia Voigt, +33

Immunity

Promote MetastasisNk Cell FunctionCancer ImmunosurveillanceImmunologyCancer Cells +5

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer

Uta M. Demel, Marlitt Böger, Schayan Yousefian, +25

Journal of Clinical Investigation

HistocompatibilityMhc ClassImmunologyImmunoeditingAntigen Processing +14

Interleukin-37 monomer is the active form for reducing innate immunity

Elan Eisenmesser, Adrian Gottschlich, Jasmina S. Redzic, +9

Proceedings of the National Academy of Sciences

Innate Immune SystemImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +21

Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function

Matthias Seifert, Mohamed-Reda Benmebarek, Daria Briukhovetska, +18

British Journal of Cancer

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Kami Pekayvaz, Corinna Losert, Viktoria Knottenberg, +33

Nature Medicine