Eric B. Springman

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

Eric B. Springman, Eddie L. Angleton, Henning Birkedal‐Hansen et al. · Proceedings of the National Academy of Sciences · 1990 · 712 citations

Life Sciences, Biochemistry, Molecular Biology +13

Design and Synthesis of Tri-Ring P₃ Benzamide-Containing Aminonitriles as Potent, Selective, Orally Effective Inhibitors of Cathepsin K

James T. Palmer, Clifford Bryant, Dan-Xiong Wang et al. · Journal of Medicinal Chemistry · 2005 · 94 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Analysis of Imatinib and Sorafenib Binding to p38α Compared with c-Abl and b-Raf Provides Structural Insights for Understanding the Selectivity of Inhibitors Targeting the DFG-Out Form of Protein Kinases

H.V.M. Namboodiri, Marina Bukhtiyarova, Joseph Ramcharan et al. · Biochemistry · 2010 · 74 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Expression, Crystallization, and Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein

Jie Tang, Christine Yu, Steven R. Williams et al. · Journal of Biological Chemistry · 2005 · 69 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38α mitogen-activated protein kinase

David J. Casper, Marina Bukhtiyarova, Eric B. Springman · Analytical Biochemistry · 2003 · 63 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17