Jon Karpilow

3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

Amanda Birmingham, Emily M. Anderson, Angela Reynolds et al. · Nature Methods · 2006 · 880 citations

Transcriptional Regulation, Functional Genomics, Natural Sciences +14

Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing

Aimee L. Jackson, Julja Burchard, Devin Leake et al. · RNA · 2006 · 781 citations · Full text

Rna Processing, Transcriptional Regulation, Rna Duplex +15

Off-target effects by siRNA can induce toxic phenotype

Yuriy Fedorov, Emily M. Anderson, Amanda Birmingham et al. · RNA · 2006 · 489 citations · Full text

Genetics, Epigenetics, Toxicological Mechanism +16

Induction of the interferon response by siRNA is cell type– and duplex length–dependent

Angela Reynolds, Emily M. Anderson, Annaleen Vermeulen et al. · RNA · 2006 · 317 citations · Full text

The contributions of dsRNA structure to Dicer specificity and efficiency

Annaleen Vermeulen, Linda S. Behlen, Angela Reynolds et al. · RNA · 2005 · 279 citations · Full text