Hemme J. Hijma

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults

Hemme J. Hijma, Pieter Siebenga, Marieke L. de Kam et al. · Pain Medicine · 2021 · 57 citations · Full text

Nursing, Pharmacokinetics, Pharmacology +17

Neurocognitive Effect of Biased µ-Opioid Receptor Agonist Oliceridine, a Utility Function Analysis and Comparison with Morphine

Laurence Moss, Hemme J. Hijma, Mark A. Demitrack et al. · Anesthesiology · 2023 · 21 citations

Medicine, Pharmacokinetics, Pharmacology +16

Challenging the challenge: A randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development

Hemme J. Hijma, Laurence Moss, Pim Gal et al. · Brain Behavior and Immunity · 2020 · 20 citations · Full text

Nursing, Pharmacology, Inflammation +16

Analgesic drug development: proof-of-mechanism and proof-of-concept in early phase clinical studies

Hemme J. Hijma, Geert Jan Groeneveld · Medicine in Drug Discovery · 2021 · 20 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Na_v1.8 inhibitor, in healthy adults

Hemme J. Hijma, Emilie M.J. van Brummelen, Pieter Siebenga et al. · Clinical and Translational Science · 2021 · 20 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16