Casim A. Sarkar - Concepedia

Author

Casim A. Sarkar

University of Pennsylvania ORCID

Also Known As

C A Sarkar, C. A. Sarkar, C.A. Sarkar, Casim A Sarkar, Casim A. Sarkar, Casim Sarkar, Casim A. Sarkar, Chandni Sarkar

Publications

1.7K

Citations

H-Index

Concepts

All Affiliations

University of Pennsylvania University of Minnesota University of Zurich Massachusetts Institute of Technology Amgen (United States)

About

Casim A. Sarkar is an author at University of Pennsylvania specializing in medicine, molecular biology, and systems biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	12	13	732
2	Engineering	7	7	371
3	Natural Sciences	4	4	118
4	Biochemistry	2	2	47
5	Health Sciences	1	1	22

Casim A. Sarkar

Publications

1.5K

Citations

H-Index

Page 1

	Year	Citations
Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity Casim A. Sarkar, Igor Dodevski, Manca Kenig, Proceedings of the National Academy of Sciences	2008	197
Tunable Signal Processing in Synthetic MAP Kinase Cascades Ellen C. O’Shaughnessy, Santhosh Palani, James J. Collins, Cell Signal TransductionEngineeringReceptor Tyrosine KinaseSynthetic BiologyMolecular Biology	2011	155
Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching” Casim A. Sarkar, Ky Lowenhaupt, Thomas P. Horan, Nature Biotechnology CytokineSignal TransductionRational Cytokine DesignPh-activated “ HistidineMedicine	2002	152
Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanism Susanne Kubetzko, Casim A. Sarkar, Andreas Plückthun Molecular Pharmacology	2005	148
Robust Network Topologies for Generating Switch-Like Cellular Responses Najaf A. Shah, Casim A. Sarkar PLoS Computational Biology EngineeringGeneticsNetwork PlanningGenomic MechanismNetwork Robustness	2011	107
Engineering Signal Peptides for Enhanced Protein Secretion from Lactococcus lactis Daphne T. W. Ng, Casim A. Sarkar Applied and Environmental Microbiology	2012	75
Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High FcγRIIa Affinity and Selectivity Sang Taek Jung, William Kelton, Tae Hyun Kang, ACS Chemical Biology Microbial PathogensImmunologyImmunoeditingImmunodominanceImmunologic Mechanism	2012	68
Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions Wesley J. Errington, Bence Bruncsics, Casim A. Sarkar Proceedings of the National Academy of Sciences	2019	65
Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution Christian Zahnd, Casim A. Sarkar, Andreas Plückthun Protein Engineering Design and Selection FitnessAffinity Maturation StrategiesGeneticsMolecular BiologyEvolutionary Multimodal Optimization	2010	55
Positive Receptor Feedback during Lineage Commitment Can Generate Ultrasensitivity to Ligand and Confer Robustness to a Bistable Switch Santhosh Palani, Casim A. Sarkar Biophysical Journal Confer RobustnessSignal TransductionSignaling PathwayG Protein-coupled ReceptorFunctional Selectivity	2008	44

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