Casim A. Sarkar

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

Casim A. Sarkar, Igor Dodevski, Manca Kenig et al. · Proceedings of the National Academy of Sciences · 2008 · 197 citations · Full text

Tunable Signal Processing in Synthetic MAP Kinase Cascades

Ellen C. O’Shaughnessy, Santhosh Palani, James J. Collins et al. · Cell · 2011 · 155 citations · Full text

Signal Transduction, Engineering, Receptor Tyrosine Kinase +9

Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching”

Casim A. Sarkar, Ky Lowenhaupt, Thomas P. Horan et al. · Nature Biotechnology · 2002 · 152 citations

Cytokine, Signal Transduction, Rational Cytokine Design +10

Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanism

Susanne Kubetzko, Casim A. Sarkar, Andreas Plückthun · Molecular Pharmacology · 2005 · 148 citations

Robust Network Topologies for Generating Switch-Like Cellular Responses

Najaf A. Shah, Casim A. Sarkar · PLoS Computational Biology · 2011 · 107 citations · Full text

Engineering, Genetics, Network Planning +21