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Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching”

CytokineSignal TransductionRational Cytokine DesignPh-activated “ HistidineMedicineImmunologyImmunologic MechanismImmunomodulationIncreased LifetimeTolerance InductionPharmacologyCell SignalingCellular Physiology