Sven Van Brandt

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

Miriam E. Jaax, Krystin Krauel, Thomas Marschall et al. · Blood · 2013 · 156 citations · Full text

Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes

Krystin Krauel, Claudia E. Weber, Sven Van Brandt et al. · Blood · 2012 · 120 citations · Full text

Characterisation of the conformational changes in platelet factor 4 induced by polyanions: towards in vitro prediction of antigenicity

Sven Van Brandt, Krystin Krauel, Kay E. Gottschalk et al. · Thrombosis and Haemostasis · 2014 · 80 citations

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

Frederik Rombouts, Gary Tresadern, Óscar Delgado et al. · Journal of Medicinal Chemistry · 2015 · 76 citations · Full text

Pharmacotherapy, Hit Generation, Pharmaceutical Chemistry +21

Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4

Martin Kreimann, Sven Van Brandt, Krystin Krauel et al. · Blood · 2014 · 75 citations