Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking

Qian Yang, Gayani Nanayakkara, Charles Drummer, +14

Frontiers in Physiology

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

Fatma Saaoud, Lu Liu, Keman Xu, +16

JCI Insight

Inflammatory Lung DiseaseLung InflammationLipid PeroxidationImmunologyRenal Inflammation +23

Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling

Wen Shen, Chao Gao, Ramón Cueto, +9

Redox Biology

Epigenetic ChangeGeneticsMolecular BiologyMetabolic RemodelingDisease Gene Identification +22

A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Luqiao Wang, Gayani Nanayakkara, Qian Yang, +20

Journal of Hematology & Oncology

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

Jahaira Lopez‐Pastrana, Lucas Ferrer, Yafeng Li, +12

Journal of Biological Chemistry

Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury

Ying Shao, Gayani Nanayakkara, Jiali Cheng, +5

Antioxidants and Redox Signaling

Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

Xin Wang, Yafeng Li, Gayani Nanayakkara, +9

Journal of Cardiovascular Translational Research

InflammationTherapeutic PotentialAnti-inflammatoryLysophospholipid ReceptorsMedicine +10

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages

Charles Drummer, Fatma Saaoud, Nirag Jhala, +17

Frontiers in Immunology

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Yafeng Li, Gayani Nanayakkara, Yu Sun, +13

Journal of Hematology & Oncology

Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells

Michael Jan, Ramón Cueto, Xiaohua Jiang, +10

Redox Biology