CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Namrata Bahadur, Julian Leathart, Elaine Mutch, +11

Biochemical Pharmacology

MedicineLiver PhysiologyHuman PolymorphismPathologyPharmacogenomics +8

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.

Aimée Paulussen, Karel Lavrijsen, Hilde Bohets, +5

Pharmacogenetics

GeneticsHuman PolymorphismPathologyMolecular GeneticsPharmacotherapy +18

The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation

Martijn P. Lolkema, Hilde Bohets, Hendrik‐Tobias Arkenau, +7

Clinical Cancer Research

Correlation between the in vitro cytotoxicity to cultured fathead minnow fish cells and fish lethality data for 50 chemicals

João Brandão, Hilde Bohets, Ingrid E. Van De Vyver, +1

Chemosphere

MedicineToxicologyToxicological AspectCell BiologyExperimental Toxicology +4

Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells

Hilde Bohets, Martine N. Van Thielen, Inge Van Der Biest, +6

Kidney International

MedicinePathologyToxicologyMetal ToxicityMercury Compounds +3

Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: <i>in vitro</i> studies of potential co‐medication interactions

Hilde Bohets, Karel Lavrijsen, Jan Hendrickx, +5

British Journal of Pharmacology

Molecular PharmacologyPotential Co‐medication InteractionsPharmacological StudyBiochemistryMedicine +12

The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in <i>Candida albicans</i> , <i>Trichophyton</i> spp., and <i>Microsporum canis</i>

H. Vanden Bossche, Jannie Ausma, Hilde Bohets, +5

Antimicrobial Agents and Chemotherapy

Ergosterol SynthesisBiosynthesisAntifungal AgentBiochemistryAntifungal Agents +11

Clinical Pharmacology of Alcaftadine, a Novel Antihistamine for the Prevention of Allergic Conjunctivitis

Hilde Bohets, Claude McGowan, Geert Mannens, +3

Journal of Ocular Pharmacology and Therapeutics

Effects of foetal calf serum on cell viability, cytotoxicity and detoxification in the two kidney-derived cell lines LLC-PK1 and MDCK

Hilde Bohets, E.J. Nouwen, Marc E. De Broe, +1

Toxicology in Vitro

UrologyFoetal Calf SerumHematologyCell DeathCell Viability +6

Correlations between Factors Determining the Pharmacokinetics and Antiviral Activity of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors of the Diaryltriazine and Diarylpyrimidine Classes of Compounds

Paul Lewi, Eddy Arnold, Koen Andries, +18

Drugs in R&D

Diarylpyrimidine ClassesAntiviral ActivityMedicineAntiviral TherapyResistance Mutation (Virology) +7