Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Bernard Côté, Jason D. Burch, Ernest Asante‐Appiah, +33

Bioorganic & Medicinal Chemistry Letters

MedicineAntiviral Drug DevelopmentAntiviral TherapyMolecular BiologyVirology +9

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

Mélina Girardin, Stéphane G. Ouellet, Danny Gauvreau, +5

Organic Process Research & Development

α-Methylpiperidine CoreConvergent Kilogram-scale SynthesisOrexin Receptor AntagonistChemical BiologyPharmaceutical Chemistry +14

A Robust Kilo-Scale Synthesis of Doravirine

Louis‐Charles Campeau, Qinghao Chen, Danny Gauvreau, +8

Organic Process Research & Development

Medicinal ChemistryNatural SciencesMedicineHiv InfectionAntiviral Drug Development +12

Cu-Catalyzed N-Arylation of Oxazolidinones:  An Efficient Synthesis of the κ-Opioid Receptor Agonist CJ-15161

Arun K. Ghosh, Janice E. Sieser, Stéphane Caron, +3

The Journal of Organic Chemistry

Synthesis of Highly Functionalized Bicyclo[<i>m</i>.<i>n</i>.1]alkanones via a Cationic Reaction Cascade

Roch M. A. Lavigne, Maxime Riou, Mélina Girardin, +2

Organic Letters

Chemical EngineeringAcid-mediated Prins/pinacolEngineeringCross-coupling ReactionHeterocyclic +11

Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines

Mélina Girardin, Pamela G. Alsabeh, Sophie Lauzon, +3

Organic Letters

Oxidation ProtocolNatural SciencesDiversity-oriented SynthesisOrganic ChemistryHigh Yield +5

Phosphine-Mediated [4 + 2] Annulation of Bis(enones):  A Lewis Base Catalyzed “Mock Diels−Alder” Reaction

Michel Couturier, Fréderic Ménard, John A. Ragan, +6

Organic Letters

Lewis-base-catalyzed CycloisomerizationChemical EngineeringEngineeringDiels-alder CycloadditionTraditional Lewis Acid +8

Development of a Practical Synthesis of Stearoyl-CoA Desaturase (SCD1) Inhibitor MK-8245

Mélina Girardin, Sarah J. Dolman, Sophie Lauzon, +5

Organic Process Research & Development

Medicinal ChemistryStearoyl-coa DesaturasePractical SynthesisPiperidine FragmentBiochemistry +11

Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate

Brian M. Andresen, Brian C. Vanderplas, John L. Tucker, +12

CHIMIA International Journal for Chemistry

PharmacotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryOriginal Discovery Synthesis +15

Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors

Jean‐Philippe Leclerc, Jean‐Pierre Falgueyret, Mélina Girardin, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetLiver-targeted Scd InhibitorsBiochemistryMedicine +6