James Root

<i>In vitro</i>and<i>in vivo</i>characterization of PF‐04418948, a novel, potent and selective prostaglandin EP₂receptor antagonist

KJ af Forselles, James Root, Tracey L. Clarke et al. · British Journal of Pharmacology · 2011 · 157 citations · Full text

Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

Robert S. Palmer, Jukka Mäenpää, Alexandra Jauhiainen et al. · Clinical Pharmacology & Therapeutics · 2018 · 90 citations · Full text

Inflammation, Asthma, Anti-inflammatory +15

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

Kevin Doyle, Hans Lönn, Helena Käck et al. · Journal of Medicinal Chemistry · 2016 · 80 citations · Full text

Drug Target, Clinical Candidate, Pharmacotherapy +19

Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition

Annika Åstrand, Martin Hemmerling, James Root et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2014 · 75 citations · Full text

Inflammatory Lung Disease, Lung Inflammation, Ciliary Beating +16

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

Joan Antoni Fernández-Blanco, Dalia Fakih, Liisa Arike et al. · JCI Insight · 2018 · 55 citations · Full text

Asthma, Inflammation, Protein Content +15