Sylvia Musto

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

Frank Loganzo, Xingzhi Tan, Matthew Sung et al. · Molecular Cancer Therapeutics · 2015 · 270 citations

Medicine, Immunology, Oncology +17

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules

Malathi Hari, Frank Loganzo, Tami Annable et al. · Molecular Cancer Therapeutics · 2006 · 147 citations

Medicine, Oncology, Pharmacology +17

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Frank Loganzo, Carolyn Discafani, Tami Annable et al. · PubMed · 2003 · 137 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

Andreas Maderna, Matthew Doroski, Chakrapani Subramanyam et al. · Journal of Medicinal Chemistry · 2014 · 132 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis, Molecular Editing, and Biological Assessment of the Potent Cytotoxin Leiodermatolide

Damien Mailhol, Jens Willwacher, Nina Kausch‐Busies et al. · Journal of the American Chemical Society · 2014 · 94 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16