Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

Herman Burger, Hans van Tol, Antonius W.M. Boersma, +4

Blood

Large-Scale Genetic Perturbations Reveal Regulatory Networks and an Abundance of Gene-Specific Repressors

Patrick Kemmeren, Katrin Sameith, Loes A. L. van de Pasch, +23

Cell

Systems BiologyFunctional GenomicsEngineeringGeneticsBiological Network +10

The Specificity and Topology of Chromatin Interaction Pathways in Yeast

Tineke L. Lenstra, Joris J. Benschop, Tae Soo Kim, +17

Molecular Cell

ChromatinCell DivisionChromatin RemodelingNatural SciencesTranscription Regulation +9

Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps

Herman Burger, Hans van Tol, Mariël Brok, +7

Cancer Biology & Therapy

Cancer ResearchOncologyDrug Transport PumpsTumor MicroenvironmentImatinib Mesylate +13

Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways

Sake van Wageningen, Patrick Kemmeren, Philip Lijnzaad, +22

Cell

Signal TransductionFunctional GenomicsGeneticsGene ExpressionSignaling Pathways +11

Cell cycle population effects in perturbation studies

Eoghan O’Duibhir, Philip Lijnzaad, Joris J. Benschop, +7

Molecular Systems Biology

Cell DivisionCell ProliferationPerturbation StudiesCell CycleMedicine +2

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

Michael T. Meister, Marian J.A. Groot Koerkamp, Terezinha de Souza, +26

EMBO Molecular Medicine

Tumor HeterogeneityPathologyRhabdomyosarcoma SubtypesMedicineTumor Biology

Anticancer Drug Resistance Induced by Disruption of the Saccharomyces cerevisiae NPR2 Gene: a Novel Component Involved in Cisplatin- and Doxorubicin-Provoked Cell Kill

Paul W. Schenk, Mariël Brok, Antonius W.M. Boersma, +6

Molecular Pharmacology

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Jeff DeMartino, Michael T. Meister, Lindy L. Visser, +10

Nature Communications

Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification

Harm van Bakel, Folkert J. van Werven, Marijana Radonjić, +4

Nucleic Acids Research

Dna MicroarraysMolecular BiologyNucleic Acid Amplification TestEpigeneticsChip Dna +16