Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

Joel M. Brittain, Djane B. Duarte, Sarah M. Wilson, +29

Nature Medicine

Molecular PhysiologyHealth SciencesNeurophysiologyPain MedicineMedicine +9

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

Rongmin Zhao, Yoshito Kakihara, Anna Gribun, +9

The Journal of Cell Biology

Molecular RegulationMolecular BiologySnorna AccumulationR2tp Complex ActivityTranscriptional Regulation +19

Discovery and characterization of small molecules that target the GTPase Ral

Chao Yan, Degang Liu, Liwei Li, +17

Nature

Protein FunctionSignal TransductionBiochemistryG Protein-coupled ReceptorNatural Sciences +7

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

Erik T. Dustrude, Aubin Moutal, Xiaofang Yang, +3

Proceedings of the National Academy of Sciences

Biophysical ModelingSynaptic TransmissionSignal RecognitionMolecular BiologyMolecular Pain +19

Synthesis and characterisation of titanium nitride based nanoparticles

Stefan Kaskel, Klaus Schlichte, Gérald Chaplais, +1

Journal of Materials Chemistry

NanoparticlesUltrafine Tin PowdersEngineeringNanoheterogeneous CatalysisChemistry +17

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

Liberty François‐Moutal, Yue Wang, Aubin Moutal, +9

Pain

Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases

May Khanna, Che-Hong Chen, Ann C. Kimble-Hill, +8

Journal of Biological Chemistry

Aldo-keto ReductaseMolecular PharmacologyMedicinal ChemistryStructure-function Enzyme KineticsAldehyde Dehydrogenases +16

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Aubin Moutal, Xiaofang Yang, Wennan Li, +14

Pain

Pain MedicinePathologyNeuropathic PainMolecular PainNf1 Pain +16

Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a <i>Drosophila</i> Model of Amyotrophic Lateral Sclerosis (ALS)

Liberty François‐Moutal, Razaz Felemban, David D. Scott, +7

ACS Chemical Biology

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

Aubin Moutal, Lindsey A. Chew, Xiaofang Yang, +14

Pain