Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development

Wanyang Liu, Daisuke Morito, Seiji Takashima, +20

PLoS ONE

EDEM3, a Soluble EDEM Homolog, Enhances Glycoprotein Endoplasmic Reticulum-associated Degradation and Mannose Trimming

Kazuyoshi Hirao, Yuko Natsuka, Taku Tamura, +9

Journal of Biological Chemistry

Glycoprotein EradGlycobiologyMolecular BiologyMannose TrimmingProtein Expression +14

Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

Daisuke Morito, Kazuyoshi Hirao, Yukako Oda, +6

Molecular Biology of the Cell

Endoplasmic Reticulum-associated DegradationProteasomeMolecular BiologyEr DegradationProteomics +15

The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets

Munechika Sugihara, Daisuke Morito, Shiori Ainuki, +5

The Journal of Cell Biology

Cytoplasmic Lipid DropletsBiochemistryNatural SciencesMetabolic RegulationMembrane Biology +11

Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients

Toshiaki Hitomi, Toshiyuki Habu, Hatasu Kobayashi, +17

Biochemical and Biophysical Research Communications

Induced Pluripotent Stem CellAngiogenesisMedicineEndothelial DysfunctionAngiogenic Activity +8

Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state

Daisuke Morito, Kouki Nishikawa, Jun Hoseki, +6

Scientific Reports

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

Janine Kirstein, Daisuke Morito, Taichi Kakihana, +8

The EMBO Journal

InflammationReductive StressAgingRedox RegulatorLongevity +11

Dual-Site Recognition of Different Extracellular Matrix Components by Anti-Angiogenic/Neurotrophic Serpin, PEDF

N. Yasui, Terumi Mori, Daisuke Morito, +4

Biochemistry

Tissue EngineeringGlycobiologyCytoskeletonBiomedical EngineeringAngiogenesis +19

ER Stress Proteins in Autoimmune and Inflammatory Diseases

Daisuke Morito, Kazuhiro Nagata

Frontiers in Immunology

ImmunologyEr StressInflammationAutophagyAutoantibodies +16

The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality

Toshiaki Hitomi, Toshiyuki Habu, Hatasu Kobayashi, +17

Biochemical and Biophysical Research Communications

Disease MechanismGenetic DisorderGeneticsPathogenesisPathology +6