Ellen Xia

Selective small-molecule inhibition of an RNA structural element

John A. Howe, Hao Wang, Thierry Fischmann et al. · Nature · 2015 · 417 citations

Life Sciences, Biochemistry, Molecular Biology +11

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

Bruce A. Malcolm, R. Liu, Frederick Lahser et al. · Antimicrobial Agents and Chemotherapy · 2006 · 318 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Characterization of resistance mutations against HCV ketoamide protease inhibitors

Xinchun Tong, Stéphane Bogen, Robert A. Chase et al. · Antiviral Research · 2008 · 127 citations

Life Sciences, Infectious Diseases, Molecular Biology +14

The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons

Frederick Lahser, Karin Bystol, Stephanie Curry et al. · Antimicrobial Agents and Chemotherapy · 2016 · 58 citations · Full text

Medicine, Infectious Diseases, Pharmacology +17

Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms

Ling Tong, Wensheng Yu, Lei Chen et al. · Journal of Medicinal Chemistry · 2016 · 47 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17