The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Daniel N. Weinberg, Simon Papillon‐Cavanagh, Haifeng Chen, +22

Nature

Histone ModificationsChromatinChromatin RemodelingHistone Mark H3k36me2Epigenetic Change +8

Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients

Elsa Quintana, Elena Piskounova, Mark Shackleton, +5

Science Translational Medicine

Nsg Mice CorrelatesImmunologyImmunoeditingPathologyImmunotherapeutics +21

Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands

Daniel N. Weinberg, Phillip Rosenbaum, Xiao Chen, +9

Nature Genetics

ChromatinChromatin RemodelingPrc1-targeted Cpg IslandsGeneticsDna Methylation +10

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

Siddhant U. Jain, Sima Khazaei, Dylan M. Marchione, +10

Proceedings of the National Academy of Sciences

Factors affecting methane production in humans

Y. Peled, Daniel N. Weinberg, Aharon Hallak, +1

Digestive Diseases and Sciences

Greenhouse GasesEngineeringBiogasGreenhouse Gas EmissionEmissions +3

Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells

Morgan Jones, Jennifer Chase, Michelle L. Brinkmeier, +10

Journal of Clinical Investigation

GeneticsCell ProliferationEpigeneticsCell RegulationStem Cell Mobilization +15

H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells

Haifeng Chen, Bo Hu, Cynthia Horth, +10

Genome Research

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

Kartik N. Rajagopalan, Xiao Chen, Daniel N. Weinberg, +4

Proceedings of the National Academy of Sciences

PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor

Katharine L. Diehl, Eva J. Ge, Daniel N. Weinberg, +3

Proceedings of the National Academy of Sciences

Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch

Kristjan H. Gretarsson, Stephen Abini-Agbomson, Susan L. Gloor, +19

Science Advances