Sima Khazaei

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas

Manav Pathania, Nicolas Jay, Nicola Maestro et al. · Cancer Cell · 2017 · 259 citations · Full text

Neuro-oncology, Developmental Biology, Trp53 Loss +10

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Brian Krug, Nicolas Jay, Ashot S. Harutyunyan et al. · Cancer Cell · 2019 · 252 citations · Full text

Neuro-oncology, Glioma, Medicine +10

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

Siddhant U. Jain, Sima Khazaei, Dylan M. Marchione et al. · Proceedings of the National Academy of Sciences · 2020 · 90 citations · Full text

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone

Sima Khazaei, Nicolas Jay, Shriya Deshmukh et al. · Cancer Discovery · 2020 · 69 citations · Full text

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

Sima Khazaei, Carol Chen, Augusto Faria Andrade et al. · Cell · 2023 · 60 citations · Full text

Neurodegenerative Diseases, Single Substitution, Medicine +9