K Akahane

Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites

K Akahane, Masayasu Sekiguchi, T Une et al. · Antimicrobial Agents and Chemotherapy · 1989 · 155 citations

Gaba Receptor Sites, Molecular Biology, Pharmacotherapy +17

Involvement of inhibitory and excitatory neurotransmitters in levofloxacin- and ciprofloxacin-induced convulsions in mice

K Akahane, M. Kato, Satoshi Takayama · Antimicrobial Agents and Chemotherapy · 1993 · 58 citations · Full text

Ciprofloxacin-induced Convulsions, Neurotransmitter, Pharmacotherapy +19

Significance of the methyl group on the oxazine ring of ofloxacin derivatives in the inhibition of bacterial and mammalian type II topoisomerases

Kazuki Hoshino, K. Satō, K Akahane et al. · Antimicrobial Agents and Chemotherapy · 1991 · 45 citations · Full text

Bioorganic Chemistry, Antibiotic Adjuvant, Oxazine Ring +16

Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites

K Akahane, Yasuharu Kimura, Yumi Tsutomi et al. · Antimicrobial Agents and Chemotherapy · 1994 · 32 citations · Full text

Pharmacotherapy, Drug Resistance, Medicinal Chemistry +17

Inhibition of GABA A Receptor Chloride Channel by Quinolones and Norfloxacin-Biphenylacetic Acid Hybrid Compounds

Yoshihisa Ito, Tomohiro Miyasaka, Hiroyuki Fukuda et al. · Neuropharmacology · 1996 · 15 citations

Biochemistry, Functional Selectivity, Medicine +6