Laetitia Francelle

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle et al. · PLoS Biology · 2017 · 212 citations · Full text

Mitophagy, Sirtuin Genes, Immunology +18

Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking

Iva Stojkovska, Willayat Yousuf Wani, Friederike Zunke et al. · Neuron · 2021 · 110 citations · Full text

Neurodegenerative Diseases, Er Proteostasis, Synaptic Signaling +10

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

David Blum, Federico Herrera, Laetitia Francelle et al. · Human Molecular Genetics · 2014 · 85 citations · Full text

Molecular Biology, Cytoskeleton, Subcellular Distribution +17

High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes

Jérémie Charbord, Pauline Poydenot, Caroline Bonnefond et al. · Stem Cells · 2013 · 81 citations

Rest Expression, High Throughput, Experimental Neuropathology +19

In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease

Jérémy Pépin, Laetitia Francelle, María-Angeles Carrillo-de Sauvage et al. · NeuroImage · 2016 · 81 citations · Full text

Vivo Imaging, Knock-in Mouse Model, Neurochemical Biomarkers +18