David Longmire

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Sharan K. Bagal, Clare Gregson, Daniel H. O’Donovan et al. · Journal of Medicinal Chemistry · 2021 · 27 citations · Full text

Chemoprevention Strategy, Epigenetic Change, Efficacious Inhibitors +22

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

James S. Scott, Bernard Barlaam, Paul R. J. Davey et al. · ACS Medicinal Chemistry Letters · 2020 · 18 citations · Full text

Late Stage Functionalization, Pharmaceutical Science, Bioorganic Chemistry +17

Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

Alexander Kapustin, Paul R. J. Davey, David Longmire et al. · Communications Biology · 2021 · 17 citations · Full text

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

James S. Scott, Darren Stead, Bernard Barlaam et al. · Journal of Medicinal Chemistry · 2023 · 16 citations

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

Philipp M. Cromm, Hélène Adihou, Shobhna Kapoor et al. · ChemBioChem · 2019 · 10 citations · Full text