Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons

Pablo Rozas, Pablo Lazcano, Ricardo Piña, +7

Pain

ApoptosisImmunologyImmune RegulationRenal InflammationMolecular Pain +28

TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons

Rodrigo Sandoval, Pablo Lazcano, Franco Ferrari, +3

Frontiers in Physiology

Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells

Mahmoud Suliman, Kendall C. Case, Michael W. Schmidtke, +3

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Cell PhysiologyHek293t CellsSignal TransductionMolecular PhysiologyInositol Depletion +10

Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function

Vaishnavi Raja, Michael Salsaa, Amit Joshi, +9

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Cell PhysiologyCardiomyopathySignal TransductionCell DivisionCell Signaling +8

Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome

Valerian E. Kagan, Yulia Y. Tyurina, Karolina Mikulska‐Ruminska, +31

Nature Metabolism

Health SciencesBiochemistryDisease MechanismLiver PhysiologyPathogenesis +11

Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase

Pablo Lazcano, Michael W. Schmidtke, Chisom Onu, +1

Journal of Biological Chemistry

NAD supplementation improves mitochondrial performance of cardiolipin mutants

Jiajia Ji, Deena Damschroder, Denise Bessert, +4

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

BiochemistryMitochondrial FunctionPhysiologyMetabolismMedicine +3

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

Claudio Coddou, Rodrigo Sandoval, Patricio A. Castro, +9

Pain

Purinergic P2x2 ReceptorCellular PhysiologyC-terminal Threonine 372Signaling PathwayReceptor Tyrosine Kinase +17

Valproate activates the Snf1 kinase in Saccharomyces cerevisiae by decreasing the cytosolic pH

Michael Salsaa, Kerestin Aziz, Pablo Lazcano, +6

Journal of Biological Chemistry