Daniel R. Whiten

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks et al. · Nature Communications · 2018 · 505 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Suman De, David C. Wirthensohn, Patrick Flagmeier et al. · Nature Communications · 2019 · 452 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

Tom Scheidt, Urszula Łapińska, Janet R. Kumita et al. · Science Advances · 2019 · 162 citations · Full text

Life Sciences, Molecular Biology, Neurodegeneration +16

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

Dezerae Cox, Daniel R. Whiten, James W. Brown et al. · Journal of Biological Chemistry · 2018 · 140 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

Suman De, Daniel R. Whiten, Francesco Simone Ruggeri et al. · Acta Neuropathologica Communications · 2019 · 101 citations · Full text

Life Sciences, Neurology, Neuroscience +17