Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

Sara Linse, Tom Scheidt, Katja Bernfur, +14

Nature Structural & Molecular Biology

Kinetic FingerprintsAlzheimer's DiseaseImmunologyMolecular BiologyProtein Misfolding +3

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

Tom Scheidt, Urszula Łapińska, Janet R. Kumita, +9

Science Advances

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

Francesco A. Aprile, Pietro Sormanni, Marina Podpolny, +15

Proceedings of the National Academy of Sciences

Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses

Jonathan Pansieri, Igor A. Iashchishyn, Hussein Fakhouri, +12

Chemical Science

Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens

Sonja Kunstmann, Tom Scheidt, Saskia Buchwald, +4

Viruses

The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces

Tom Scheidt, Jacqueline A. Carozza, Carl C. Kolbe, +13

Proceedings of the National Academy of Sciences

Protein AssemblyOligomeric ChaperonesMolecular BiologyProtein Phase SeparationAnalytical Ultracentrifugation +15

Label-Free Protein Analysis Using Liquid Chromatography with Gravimetric Detection

Tadas Kartanas, Aviad Levin, Zenon Toprakcioglu, +4

Analytical Chemistry

EngineeringAnalytical MicrosystemsBiological Mass SpectrometryBiomedical EngineeringAnalytical Ultracentrifugation +25

Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum

Matthias M. Schneider, Tom Scheidt, Ashley J. Priddey, +7

Biosensors and Bioelectronics

HlaImmunocytochemical TechniqueEngineeringImmunologyAntibody Profiling +21

Bacteriophage Tailspikes and Bacterial O-Antigens as a Model System to Study Weak-Affinity Protein–Polysaccharide Interactions

Yu Kang, U. Gohlke, Olof Engström, +7

Journal of the American Chemical Society

Protein AssemblyBiomolecular Structure PredictionBacterial Surface PolysaccharidesBacteriologyBacteriophage +18

Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum

Matthias M. Schneider, Tom Scheidt, Ashley J. Priddey, +7

HlaImmunocytochemical TechniqueEngineeringIn-solution CharacterisationImmunology +22