Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Ponsawan Netcharoensirisuk, Carla Abrahamian, Rachel Tang, +12

Scientific Reports

ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma

Mattias K. Andersson, Giovanna Mangiapane, Paloma Tejera Nevado, +11

Oncogenesis

Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors

Philipp Rühl, Anna Scotto Rosato, Nicole Urban, +10

Scientific Reports

<scp>TPC2</scp> rescues lysosomal storage in mucolipidosis type <scp>IV</scp> , <scp>Niemann–Pick</scp> type <scp>C1,</scp> and Batten disease

Anna Scotto Rosato, Einar Krogsaeter, Dawid Jaślan, +27

EMBO Molecular Medicine

Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes

Yu Yuan, Dawid Jaślan, Taufiq Rahman, +13

Nature Communications

Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing

Perihan A. Elzahhar, Hisham A. Nematalla, Houssam Al-Koussa, +3

Journal of Medicinal Chemistry

Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis

Carla Abrahamian, Rachel Tang, Rebecca Deutsch, +19

Nature Communications

Endolysosomal TRPML1 channel regulates cancer cell migration by altering intracellular trafficking of E-cadherin and β1-integrin

Nadine Frey, Lina Ouologuem, Julia Blenninger, +8

Journal of Biological Chemistry