Steered Molecular Dynamics Simulations for Studying Protein–Ligand Interaction in Cyclin-Dependent Kinase 5

Jagdish Suresh Patel, Anna Berteotti, Simone Ronsisvalle, +2

Journal of Chemical Information and Modeling

Drug TargetMolecular BiologyMolecular DynamicsSmall MoleculesSystems Pharmacology +22

Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile

Laura Ielo, Batel Deri, Maria Paola Germanò, +10

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicine +7

Effect of hyaluronic acid and polysaccharides from Opuntia ficus indica (L.) cladodes on the metabolism of human chondrocyte cultures

Anna Maria Panico, Venera Cardile, F. Garufi, +3

Journal of Ethnopharmacology

Human Chondrocyte CulturesHyaluronic AcidOpuntia Ficus IndicaPhysiologyPolysaccharide +3

Anti-Amnesic and Neuroprotective Actions of the Sigma-1 Receptor Agonist (-)-MR22 in Rats with Selective Cholinergic Lesion and Amyloid Infusion

Vuokko Antonini, Agostino Marrazzo, Giulio Kleiner, +5

Journal of Alzheimer s Disease

Synaptic TransmissionSigma-1 Receptor AgonistNeurochemical BiomarkersClinical NeuroscienceSynaptic Signaling +21

Anti‐amnesic properties of (±)‐PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats

Vuokko Antonini, Orazio Prezzavento, Marino Coradazzi, +4

Journal of Neurochemistry

Identification of a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells

Daniela Rossi, Alice Pedrali, Mariangela Urbano, +13

Bioorganic & Medicinal Chemistry

Molecular PharmacologyPc12 CellsSignal TransductionSignaling PathwayG Protein-coupled Receptor +7

The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures

Carmela Parenti, Rita Turnaturi, Giuseppina Aricò, +8

Neuropharmacology

Molecular NeuroscienceMedicinePersistent PainNeuropathic PainMolecular Pain +8

In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia

Agostino Marrazzo, Carmela Parenti, Valentina Scavo, +3

Life Sciences

Kop Supraspinal AnalgesiaPain MedicineVivo EvaluationMedicineNeuropharmacology +3

Antibacterial and anti-biofilm activities of walnut pellicle extract (<i>Juglans regia</i> L.) against coagulase-negative staphylococci

Rosaria Acquaviva, Floriana D’Angeli, Giuseppe Antonio Malfa, +7

Natural Product Research

Evaluation of N-substitution in 6,7-benzomorphan compounds

Lorella Pasquinucci, Orazio Prezzavento, Agostino Marrazzo, +8

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences +3