Sox2 is important for two crucial processes in lung development: Branching morphogenesis and epithelial cell differentiation

Cristina Gontan, Anne de Munck, Marcel Vermeij, +3

Developmental Biology

Developmental BiologyTissue DevelopmentMorphogenesisBranching MorphogenesisEpithelial Cell Differentiation +7

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes

Erik Engelen, Umut Akinci, Jan Christian Bryne, +16

Nature Genetics

Genetic DisorderGeneticsGenomic MechanismGene RegulationHuman Syndromes +4

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

Cristina Gontan, Eskeatnaf Mulugeta, Jeroen Demmers, +5

Nature

Genome InstabilityTranscriptional RegulationGeneticsChromosome BiologyX-chromosome Inactivation +3

RNF12 Activates Xist and Is Essential for X Chromosome Inactivation

Tahsin Stefan Barakat, Nilhan Gunhanlar, Cristina Gontan, +7

PLoS Genetics

RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation

Long Zhang, Huizhe Huang, Fangfang Zhou, +11

Molecular Cell

Developmental BiologySignaling PathwayMedicineZebrafish EmbryosStem Cell Research +7

Sox2 Regulates the Emergence of Lung Basal Cells by Directly Activating the Transcription of <i>Trp63</i>

Joshua K. Ochieng, Kim Schilders, Heleen Kool, +8

American Journal of Respiratory Cell and Molecular Biology

Lung InflammationMolecular RegulationGeneticsOrgan DevelopmentCell Specialization +21

Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors

Cristina Gontan, Thomas Güttler, Erik Engelen, +7

The Journal of Cell Biology

REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

Cristina Gontan, Hegias Mira-Bontenbal, Aristea Magaraki, +5

Nature Communications

SPEN is required for Xist upregulation during initiation of X chromosome inactivation

Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, +10

Nature Communications

Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder

Suzanna G.M. Frints, Ayşegül Ozantürk, Germán Rodríguez Criado, +41

Molecular Psychiatry

Mendelian DisorderGenetic DisorderGeneticsPsychiatric GeneticsBehavior Disorder +6