Alvin Chen

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Jonathan B. Rosenberg, Michael G. Kaplitt, Bishnu P. De et al. · Human Gene Therapy Clinical Development · 2018 · 152 citations · Full text

Neurochemical Biomarkers, Social Sciences, Apoe2 Expression +18

Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss

Oyundari Amartuvshin, Chi‐Hung Lin, Shao‐Chun Hsu et al. · Aging Cell · 2020 · 74 citations · Full text

Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing <i>CLN2</i>

Dolan Sondhi, Stephen M. Kaminsky, Neil R. Hackett et al. · Science Translational Medicine · 2020 · 67 citations · Full text

Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies

Zheng Guo, Alvin Chen, Roger A. Nassar et al. · Pharmaceutical Research · 2012 · 65 citations

Medicine, Antibody Screening, Structure-activity Relationship +7

Comparative Efficacy and Safety of Multiple Routes of Direct CNS Administration of Adeno-Associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human Arylsulfatase A cDNA to Nonhuman Primates

Jonathan B. Rosenberg, Dolan Sondhi, David G. Rubin et al. · Human Gene Therapy Clinical Development · 2014 · 59 citations · Full text

White Matter, Immunology, Experimental Pathology +20