Andrew J. Eatherton

Discovery of 2-[(2,4-Dichlorophenyl)amino]- <i>N</i> -[(tetrahydro- 2 <i>H</i> -pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a Selective CB2 Receptor Agonist for the Treatment of Inflammatory Pain

Gerard M.P. Giblin, Celestine T. O’Shaughnessy, Alan Naylor et al. · Journal of Medicinal Chemistry · 2007 · 120 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Total Synthesis of Wasabidienones B₁ and B₀ via SIBX-Mediated Hydroxylative Phenol Dearomatization

Laurent Pouységu, Mélanie Marguerit, Julien Gagnepain et al. · Organic Letters · 2008 · 71 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2022 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

Discovery of 1-[4-(3-Chlorophenylamino)-1-methyl-1<i>H</i>-pyrrolo[3,2-<i>c</i>]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a Brain Penetrant 5-Azaindole CB₂Agonist for the Treatment of Chronic Pain

Gerard M.P. Giblin, Andrew Billinton, Michael A. Briggs et al. · Journal of Medicinal Chemistry · 2009 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15