The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components

Peter C. Stirling, Michelle S. Bloom, Tejomayee Solanki-Patil, +7

PLoS Genetics

Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of <i>Subdoligranulum</i>

Meagan E. Chriswell, Adam R. Lefferts, Michael R. Clay, +15

Science Translational Medicine

IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

Qian Wang, Christin M. Lepus, Harini Raghu, +18

eLife

Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

R. Camille Brewer, Tobias V. Lanz, Caryn Hale, +32

Science Translational Medicine

Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis

Qian Wang, Kazuhiro Onuma, Changhao Liu, +21

JCI Insight

Cartilage BreakdownJoint FailureImmunologyImmune RegulationIntegrin Function +18

The Clinical Utility of Genetic Testing in the Diagnosis and Management of Adults with Chronic Kidney Disease

Neera K. Dahl, Michelle S. Bloom, Fouad T. Chebib, +16

Journal of the American Society of Nephrology

Genetic Etiologies for Chronic Kidney Disease Revealed through Next-Generation Renal Gene Panel

Anthony J. Bleyer, Maggie Westemeyer, Jing Xie, +14

American Journal of Nephrology

B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α production

Serra E. Elliott, Sarah Kongpachith, Nithya Lingampalli, +8

Clinical Immunology

Interleukin 4 promotes anti-inflammatory macrophages that clear cartilage debris and inhibits osteoclast development to protect against osteoarthritis

Ericka P. von Kaeppler, Qian Wang, Harini Raghu, +3

Clinical Immunology

InflammationCytokineAnti-inflammatoryInflammatory DiseaseImmunology +9

Genetic Testing for Chronic Kidney Diseases: Clinical Utility and Barriers Perceived by Nephrologists

Michal Mrug, Michelle S. Bloom, Christine Seto, +6

Kidney Medicine