Canagliflozin ameliorates obesity by improving mitochondrial function and fatty acid oxidation via PPARα in vivo and in vitro

Dan Wei, Lin Liao, Huanjun Wang, +3

Life Sciences

ObesityMetabolic SyndromeMitochondrial FunctionBiochemistryMedicine +8

Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial

Dalong Zhu, Jianhua Ma, Jiao’e Zeng, +42

Nature Medicine

Metabolic SyndromeDiabetes ManagementPlacebo-controlled Phase 3Drug-naïve PatientsDiabetes +6

A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity

Linong Ji, Hongwei� Jiang, Zhifeng Cheng, +18

Nature Communications

The Clinical and Pathological Characteristics of Malignant Struma Ovarii: An Analysis of 144 Published Patients

Yuying Cui, Jinming Yao, Shengnan Wang, +3

Frontiers in Oncology

Protective Effect of Salidroside Against Diabetic Kidney Disease Through Inhibiting BIM-Mediated Apoptosis of Proximal Renal Tubular Cells in Rats

Congcong Guo, Yun Li, Rui Zhang, +6

Frontiers in Pharmacology

High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells

Xiaoqian Zhang, Jianjun Dong, Tian Cai, +3

Oncotarget

ApoptosisImmunologyRenal InflammationCell DeathPathology +16

Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway

Yuhan Zhang, Yaqin Zhang, Congcong Guo, +4

Acta Pharmacologica Sinica

UrologyMedicineJnk/bim PathwayApoptosisDiabetes +9

Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction

Chunmei Xu, Xiaojun Zhou, Tianyue Xie, +6

Theranostics

Long non-coding RNA MEG3 inhibits neovascularization in diabetic retinopathy by regulating microRNA miR-6720-5p and cytochrome B5 reductase 2

Jinpeng Chen, Lin Liao, Huiyong Xu, +2

Bioengineered

Diabetic RetinopathyOphthalmologyMicrovascular DysfunctionDiabetesDr Neovascularization +11

Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction

Yan Li, Liqun Li, Fengyun Dong, +8

Experimental and Therapeutic Medicine

Heart FailureImmunologyPathologyRat ModelAcute Myocardial Infarction +20