Takushi Kanazu

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

Yuji Koriyama, Akihiro Hori, Hisanori Ito et al. · Journal of Medicinal Chemistry · 2021 · 54 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Aldehyde reductase is a major protein associated with 3-deoxyglucosone reductase activity in rat, pig and human livers

Takushi Kanazu, M Shinoda, Toshihiro Nakayama et al. · Biochemical Journal · 1991 · 53 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug–drug interaction model rats

Takushi Kanazu, Noboru Okamura, Yoshitaka Yamaguchi et al. · Xenobiotica · 2005 · 42 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine

Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi et al. · Drug Metabolism and Disposition · 2018 · 37 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Model for the drug–drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans

Takushi Kanazu, Yoshitaka Yamaguchi, Noboru Okamura et al. · Xenobiotica · 2004 · 34 citations

Medicine, Pharmacokinetics, Pharmacology +17