Aldehyde reductase is a major protein associated with 3-deoxyglucosone reductase activity in rat, pig and human livers

Takushi Kanazu, M Shinoda, Toshihiro Nakayama, +3

Biochemical Journal

Aldo-keto ReductaseMolecular BiologyRedox BiologyOxidative StressMajor Protein +14

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

Yuji Koriyama, Akihiro Hori, Hisanori Ito, +19

Journal of Medicinal Chemistry

Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug–drug interaction model rats

Takushi Kanazu, Noboru Okamura, Yoshitaka Yamaguchi, +2

Xenobiotica

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine

Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, +3

Drug Metabolism and Disposition

Model for the drug–drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans

Takushi Kanazu, Yoshitaka Yamaguchi, Noboru Okamura, +2

Xenobiotica

Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques

Mitsutaka Kitano, Yasushi Itoh, Makoto Kodama, +12

Antimicrobial Agents and Chemotherapy

Model for the drug–drug interaction responsible for CYP3A enzyme inhibition. II: establishment and evaluation of dexamethasone-pretreated female rats

Takushi Kanazu, Yoshitaka Yamaguchi, Noboru Okamura, +2

Xenobiotica

Glucuronidation Converting Methyl 1-(3,4-Dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a Potent Apical Sodium-Dependent Bile Acid Transporter Inhibitor, Resulting in a Hypocholesterolemic Action

Shingo Sakamoto, Hiroyuki Kusuhara, Kenji Miyata, +9

Journal of Pharmacology and Experimental Therapeutics

Efficacy of Repeated Intravenous Injection of Peramivir against Influenza A (H1N1) 2009 Virus Infection in Immunosuppressed Mice

Mitsutaka Kitano, Makoto Kodama, Yasushi Itoh, +4

Antimicrobial Agents and Chemotherapy

VaccinationVirus InfectionRepeated Intravenous InjectionImmunologyIntravenous Peramivir +10

Distribution and characterization of dihydrodiol dehydrogenases in mammalian ocular tissues

Akira Hara, Toshihiro Nakayama, Tatsuhiro Harada, +4

Biochemical Journal

Animal PhysiologyDihydrodiol DehydrogenasesAldehyde DehydrogenaseAlcohol DehydrogenasesBiochemistry +12