Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

Huaigeng Xu, Bo Wang, Miyuki Ono, +13

Cell stem cell

Autoimmune DiseaseCrispr-cas9 Generates IpscsGenome SurgeryGeneticsImmunology +11

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

Peter Gee, Mandy Siu Yu Lung, Yuya Okuzaki, +22

Nature Communications

Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

Bo Wang, Shoichi Iriguchi, Masazumi Waseda, +13

Nature Biomedical Engineering

Regenerative MedicineInduced Pluripotent Stem CellCell TherapyPluripotent Stem CellsMarrow Transplantation +12

CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

Hiroyuki Morisaka, Kazuto Yoshimi, Yuya Okuzaki, +12

Nature Communications

iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

Daisuke Suzuki, Charlotte Flahou, Norihide Yoshikawa, +14

Stem Cell Reports

Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application

Yuko Kitano, Sayaka Nishimura, Tomoaki Kato, +10

Molecular Therapy — Methods & Clinical Development

GeneticsImmunologyDetailed EvaluationRegenerative MedicinePluripotent Stem Cells +15

Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

Tatsuki Ueda, Sara Shiina, Shoichi Iriguchi, +17

Nature Biomedical Engineering

Efficient ssODN-Mediated Targeting by Avoiding Cellular Inhibitory RNAs through Precomplexed CRISPR-Cas9/sgRNA Ribonucleoprotein

Akihiro Kagita, Mandy Siu Yu Lung, Huaigeng Xu, +7

Stem Cell Reports

Efficient mRNA delivery system utilizing chimeric VSVG-L7Ae virus-like particles

Yulia Zhitnyuk, Peter Gee, Mandy Siu Yu Lung, +4

Biochemical and Biophysical Research Communications

Viral ReplicationVirologySynthetic Virology

Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells

Kentaro Ishida, Huaigeng Xu, Noriko Sasakawa, +4

Scientific Reports