Ashley M. Jacobi

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells

Christopher A. Vakulskas, Daniel P. Dever, Garrett R. Rettig et al. · Nature Medicine · 2018 · 801 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

Daniel Rosenblum, Anna Gutkin, Ranit Kedmi et al. · Science Advances · 2020 · 584 citations · Full text

Life Sciences, Biotechnology, Oncology +17

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Rolen M. Quadros, Hiromi Miura, Donald W. Harms et al. · Genome biology · 2017 · 572 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish

Kazuyuki Hoshijima, Michael J. Jurynec, Dana Klatt Shaw et al. · Developmental Cell · 2019 · 299 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease

Kiran Musunuru, Sarah Grandinette, Xiao Wang et al. · New England Journal of Medicine · 2025 · 278 citations · Full text

Life Sciences, Biotechnology, Molecular Genetics +17