Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

Olli Dufva, Jan Koski, Pilvi Maliniemi, +14

Blood

Immunogenomic Landscape of Hematological Malignancies

Olli Dufva, Petri Pölönen, Oscar Brück, +21

Cancer Cell

Hematological MalignancyCancer ImmunosurveillanceMedicineMalignant Blood DisorderHematology +5

Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia

Lindsey E. Montefiori, Sonja Bendig, Zhaohui Gu, +49

Cancer Discovery

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Heikki Kuusanmäki, Aino‐Maija Leppä, Petri Pölönen, +11

Haematologica

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä‐Koskela, +25

Blood

The genomic basis of childhood T-lineage acute lymphoblastic leukaemia

Petri Pölönen, Danika Di Giacomo, Anna Eames Seffernick, +56

Nature

Hematological MalignancyGenomic BasisMixed-phenotype Acute LeukemiaGeneticsHematology +4

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

Petri Pölönen, Ashik Jawahar Deen, Hanna Leinonen, +11

Oncogene

Neuro-oncologyGliomaMedicineCell BiologyTumor Suppressor +4

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia

Sarra Ryan, John F. Peden, Zoya Kingsbury, +17

Leukemia

Signalling input from divergent pathways subverts B cell transformation

Lai N. Chan, Mark A. Murakami, Mark E. Robinson, +25

Nature

Signal TransductionSignaling PathwayCell TraffickingCellular Regulatory MechanismB Cell Transformation +3

Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture

Maria Bouvy‐Liivrand, Ana Hernández de Sande, Petri Pölönen, +5

Nucleic Acids Research

EngineeringGeneticsTranscriptomics TechnologyEpigeneticsTranscriptional Regulation +24