Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

Olli Dufva, Jan Koski, Pilvi Maliniemi, +14

Blood

Immunogenomic Landscape of Hematological Malignancies

Olli Dufva, Petri Pölönen, Oscar Brück, +21

Cancer Cell

Hematological MalignancyCancer ImmunosurveillanceMedicineMalignant Blood DisorderHematology +5

Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

Disha Malani, Ashwini Kumar, Oscar Brück, +24

Cancer Discovery

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Heikki Kuusanmäki, Aino‐Maija Leppä, Petri Pölönen, +11

Haematologica

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Olli Dufva, Matti Kankainen, Tiina Kelkka, +24

Nature Communications

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä‐Koskela, +25

Blood

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

Oscar Brück, Sami Blom, Olli Dufva, +10

Leukemia

Leukemia Bone MarrowMixed-phenotype Acute LeukemiaImmunologyBiological MicroenvironmentsPathology +17

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

Emma Andersson, S. Pützer, Bhagwan Yadav, +36

Leukemia

Novel Drug SensitivitiesPharmaceutical ResearchDrug TargetSignal TransductionEngineering +10

Genome-scale screens identify factors regulating tumor cell responses to natural killer cells

Michal Sheffer, Emily Lowry, Nicky A. Beelen, +28

Nature Genetics

Tumor BiologyNatural Killer CellsCancer ImmunosurveillanceImmunologyTumor Immunity +8

Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma

Jani Huuhtanen, Henna H.E. Kasanen, Katriina Peltola, +17

Journal of Clinical Investigation

ImmunologyNk CellsImmunoeditingSingle-cell CharacterizationImmune Cell Therapy +17