Dina A. Sharon

Computation Sheds Insight into Iron Porphyrin Carbenes’ Electronic Structure, Formation, and N–H Insertion Reactivity

Dina A. Sharon, Dibyendu Mallick, Binju Wang et al. · Journal of the American Chemical Society · 2016 · 122 citations

N–h Insertion Reactivity, Inorganic Chemistry, Chemical Engineering +15

RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across <i>FGFR2</i> Alterations and Resistance Mutations

Vivek Subbiah, Vaibhav Sahai, Dejan Maglic et al. · Cancer Discovery · 2023 · 103 citations · Full text

Selective Chlorination of Substrates by the Halogenase SyrB2 Is Controlled by the Protein According to a Combined Quantum Mechanics/Molecular Mechanics and Molecular Dynamics Study

Jing Huang, Chunsen Li, Binju Wang et al. · ACS Catalysis · 2016 · 87 citations

Bioorganic Chemistry, Engineering, Molecular Biology +20

Computations Reveal a Rich Mechanistic Variation of Demethylation of <i>N</i>-Methylated DNA/RNA Nucleotides by FTO

Binju Wang, Zexing Cao, Dina A. Sharon et al. · ACS Catalysis · 2015 · 65 citations

Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

Heike Schönherr, Pelin Ayaz, Alexander M. Taylor et al. · Proceedings of the National Academy of Sciences · 2024 · 53 citations · Full text