Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Jenny C. Taylor, Hilary C. Martin, Stefano Lise, +105

Nature Genetics

SequencingPsychiatryClinical GenomeGeneticsMedicine +6

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

Natalie F. Shanks, Jeffrey N. Savas, Tomohiko Maruo, +8

Cell Reports

Synaptic TransmissionMolecular BiologyBinding ProteinSynaptic SignalingCellular Physiology +18

Structure and organization of heteromeric AMPA-type glutamate receptors

Béatriz Herguedas, Javier García‐Nafría, Ondřej Cais, +4

Science

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8

Béatriz Herguedas, Jake F. Watson, Hinze Ho, +3

Science

Gating and modulation of a hetero-octameric AMPA glutamate receptor

Danyang Zhang, Jake F. Watson, Peter M. Matthews, +2

Nature

NeurophysiologyFunctional SelectivityNeurotransmitterReceptor (Biochemistry)Neuroscience +2

Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating

Ondřej Cais, Béatriz Herguedas, Karolina Krol, +3

Cell Reports

Synaptic TransmissionAmpar Auxiliary SubunitsMolecular BiologyNeurotransmissionCellular Physiology +19

Activity-Mediated AMPA Receptor Remodeling, Driven by Alternative Splicing in the Ligand-Binding Domain

Andrew C. Penn, Aleš Balík, Christian Wozny, +2

Neuron

Temperature dependence of NR1/NR2B NMDA receptor channels

Ondřej Cais, Miloslav Sedlacek, Martin Hořák, +2

Neuroscience

Molecular PhysiologyPhysiologyTemperature DependenceReceptor (Biochemistry)Neuropharmacology +2

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability

Benjamin Davies, Laurence A. Brown, Ondřej Cais, +23

Human Molecular Genetics

Sleep DisordersGeneticsGene CharacterizationMolecular GeneticsDisease Gene Identification +16

Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor

Danyang Zhang, Josip Ivica, James Krieger, +6

Nature