C. Muto

Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate

Keita Mizuno, Toshiaki Kume, C. Muto et al. · Journal of Pharmacological Sciences · 2011 · 95 citations · Full text

Conformational Restriction Approach to β-Secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode

Shuji Yonezawa, Takahiko Yamamoto, Hidekuni Yamakawa et al. · Journal of Medicinal Chemistry · 2012 · 49 citations · Full text

Stereoisomeric Cyclopropane Compounds, Drug Target, Protein Secretion +16

Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations

Shuji Yonezawa, Kenichiro Fujiwara, Takahiko Yamamoto et al. · Bioorganic & Medicinal Chemistry · 2013 · 18 citations · Full text

Binding Mode, Protein Chemistry, Biochemistry +12

Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring

Shuji Yonezawa, Hidekuni Yamakawa, C. Muto et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 16 citations · Full text

Isocytosine Derivatives, Drug Target, Biochemistry +8